2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition

Abstract Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo. Although cPA is similar to lysophosphatidic acid (LPA) in s...

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Detalhes bibliográficos

Principais autores:	Keiko Fukasawa, Mari Gotoh, Akiharu Uwamizu, Takatsugu Hirokawa, Masaki Ishikawa, Yoshibumi Shimizu, Shinji Yamamoto, Kensuke Iwasa, Keisuke Yoshikawa, Junken Aoki, Kimiko Murakami-Murofushi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2021-08-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-021-96931-2
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