Integrative network toxicology and experimental evidence reveal mechanisms underlying diethyl phthalate-induced initiation and progression of endometrial cancer

Abstract Diethyl phthalate (DEP) is a ubiquitous environmental endocrine-disrupting chemical (EDC). Epidemiological studies have suggested a potential association between DEP exposure and an increased risk of endometrial cancer (EC); however, its underlying molecular mechanisms remain largely unclea...

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Autori principali:	Xi Chen, Zijing Wang, Fengfeng Wang, Yuexiao Wu, Dan Hu, Yuemei Cheng, Yijuan Xing, Junhong Du, Tao Jiang, Yongxiu Yang, Xiaolei Liang, Xuehan Bi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-02-01
Serie:	Scientific Reports
Soggetti:	Endometrial cancer Diethyl phthalate Network toxicology Machine learning Molecular dynamics simulation
Accesso online:	https://doi.org/10.1038/s41598-026-39325-6
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