Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region

Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID) use; and opioids’ addiction are unresolv...

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Hauptverfasser:	Hernan A. Bazan, Surjyadipta Bhattacharjee, Madigan M. Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey A. St Pierre, Neehar Desai, Patrick W. Daly, Jessica A. Cucinello-Ragland, Scott Edwards, Javier Recio, Julio Alvarez-Builla, James J. Cai, Nicolas G. Bazan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-05-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Non-opioid CNS Liver toxicity scRNA-seq Phase 1 trial
Online-Zugang:	https://doi.org/10.1038/s41598-024-61791-z
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