Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain

Abstract The growth and motility factor Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and its receptor, the product of the MET proto-oncogene, promote invasion and metastasis of tumor cells and have been considered potential targets for cancer therapy. We generated a new Met-blocking antibody whi...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Danielle M. DiCara, Dimitri Y. Chirgadze, Anthony R. Pope, Aneesh Karatt-Vellatt, Anja Winter, Peter Slavny, Joop van den Heuvel, Kothai Parthiban, Jane Holland, Len C. Packman, Georgia Mavria, Jens Hoffmann, Walter Birchmeier, Ermanno Gherardi, John McCafferty
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Nature Portfolio 2017-08-01
سلاسل:	Scientific Reports
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-017-09460-2
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!