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Synergy between HA cleavage site sequence and NA-mediated plasminogen recruitment as a virulence mechanism for low-pathogenic avian influenza

ABSTRACT An outbreak of H3N1 low-pathogenic avian influenza virus (LPAIV) in Belgium in 2019 caused unexpected levels of mortality and morbidity in poultry. These viruses possess an NA polymorphism associated with plasminogen (PLG) binding, as well as an atypical sequence around the HA cleavage site...

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Principais autores: Hui Min Lee, Kate Sutton, William Harvey, Samantha Sives, Rute Maria Pinto, Eleanor Gaunt, Samantha Lycett, Sjaak de Wit, Lonneke Vervelde, Paul Digard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2026-04-01
coleção:mBio
Assuntos:
influenza
neuraminidase
plasminogen
hemagglutinin
pathogenicity
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.02466-25
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