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PKMζ-KIBRA interactions, molecular turnover, and memory

Abstract How can the molecules that strengthen synaptic connections maintain memory in the face of molecular turnover? Our previous work showed that persistent interaction between the postsynaptic scaffolding protein, KIBRA, and the autonomously active PKC isoform, PKMζ, is crucial for maintaining s...

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Autores principales: Changchi Hsieh, David A. Cano, Panayiotis Tsokas, James E. Cottrell, André Antonio Fenton, Harel Shouval, Todd Charlton Sacktor
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2026-03-01
Colección:Molecular Brain
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Acceso en línea:https://doi.org/10.1186/s13041-026-01284-4
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