Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles

Abstract Background Alzheimer’s disease (AD) is the most prominent form of dementia worldwide. It is characterized by tau lesions that spread throughout the brain in a spatio-temporal manner. This has led to the prion-like propagation hypothesis implicating a transfer of pathological tau seeds from...

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Autors principals:	Marie Oosterlynck, Elodie Leroux, Balasubramaniam Namasivayam, Thomas Bouillet, Raphaelle Caillierez, Anne Loyens, Daniele Mazur, Romain Perbet, Christophe Lefebvre, Soulaimane Aboulouard, Claude-Alain Maurage, Bertrand Accart, Luc Buée, Morvane Colin
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-12-01
Col·lecció:	Translational Neurodegeneration
Matèries:	Alzheimer's disease Extracellular vesicles Collagenase brain dissociation Proteomic profiling GWAS FERMT2
Accés en línia:	https://doi.org/10.1186/s40035-025-00519-z
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