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Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

Abstract Two major glycosaminoglycan types, heparan sulfate (HS) and chondroitin sulfate (CS), control many aspects of development and physiology in a type-specific manner. HS and CS are attached to core proteins via a common linker tetrasaccharide, but differ in their polymer backbones. How core pr...

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Principais autores: Douglas Sammon, Anja Krueger, Marta Busse-Wicher, Rhodri Marc Morgan, Stuart M. Haslam, Benjamin Schumann, David C. Briggs, Erhard Hohenester
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2023-10-01
Series:Nature Communications
Acceso en liña:https://doi.org/10.1038/s41467-023-42236-z
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