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Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

Whether amino acids act on cellular insulin signaling remains unclear. Here, the authors find that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose uptake and positively correlated with T2D onset.

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Principais autores: Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2022-07-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-022-32000-0
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