The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease

Abstract Accumulation of alpha-synuclein (ASYN) in neurons and other CNS cell types may contribute to the underlying pathology of synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and Multiple Systems Atrophy (MSA). In support of this hypothesis for PD, ASYN immun...

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Prif Awduron:	Diana L. Price, Maya A. Koike, Asma Khan, Wolfgang Wrasidlo, Edward Rockenstein, Eliezer Masliah, Douglas Bonhaus
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2018-11-01
Cyfres:	Scientific Reports
Pynciau:	ASYN Misfolding Dementia With Lewy Bodies (DLB) Brain Penetrance University Of California At San Diego (UCSD) Tyrosine Hydroxylase
Mynediad Ar-lein:	https://doi.org/10.1038/s41598-018-34490-9
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