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From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson’s disease

Abstract The definition of Parkinson’s disease (PD) is undergoing a profound transformation from a “clinical syndrome” to a “biological entity”, with development of two objective biological classification systems, the NSD-ISS (Neuronal Alpha-Synuclein Disease Integrated Staging System) and the SynNe...

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Principais autores: Zhenwei Yu, Dongning Su, Siming Li, Shinuan Lin, Kang Ren, Tao Feng
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-05-01
coleção:Translational Neurodegeneration
Assuntos:
Parkinson’s disease
Biomarker
α-Synuclein
Seed amplification assay
Neuroimaging
Digital biomarker
Acesso em linha:https://doi.org/10.1186/s40035-026-00558-0
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