Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome

Abstract Background Fatty acid oxidation (FAO) defects have been implicated in experimental models of acute lung injury and associated with poor outcomes in critical illness. In this study, we examined acylcarnitine profiles and 3-methylhistidine as markers of FAO defects and skeletal muscle catabol...

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Autori principali:	Tomeka L. Suber, Stacy G. Wendell, Steven J. Mullett, Benjamin Zuchelkowski, William Bain, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Yingze Zhang, Faraaz Shah, Seyed Mehdi Nouraie, Janet S. Lee
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-05-01
Serie:	Respiratory Research
Soggetti:	Metabolomics Acute respiratory distress syndrome Subphenotypes Acylcarnitines Fatty acid oxidation
Accesso online:	https://doi.org/10.1186/s12931-023-02447-w
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