Comparative evaluation of GUM and Monte Carlo simulation for uncertainty estimation in LC–MS/MS: impact of input correlations and application to urinary N-desethyl blonanserin

Abstract To improve the reliability of the liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis of biological samples, it is necessary to evaluate the measurement uncertainty (MU). Although the Guide to the Expression of Uncertainty in Measurement (GUM) is widely used as an internation...

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Principais autores:	Yeong Eun Sim, Jeong Eun Kim, Ji Woo Kim, Jin Young Kim
Formato:	Artigo
Idioma:	Inglês
Publicado:	SpringerOpen 2026-06-01
Series:	Journal of Analytical Science and Technology
Assuntos:	Measurement uncertainty Guide to the Expression of Uncertainty in Measurement Monte Carlo method N‑desethyl blonanserin LC–MS/MS
Acceso en liña:	https://doi.org/10.1186/s40543-026-00550-3
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