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Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models

Summary: Functional precision medicine aims to match individual cancer patients to optimal treatment through ex vivo drug susceptibility testing on patient-derived cells. However, few functional diagnostic assays have been validated against patient outcomes at scale because of limitations of such as...

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Principais autores: Max A. Stockslager, Seth Malinowski, Mehdi Touat, Jennifer C. Yoon, Jack Geduldig, Mahnoor Mirza, Annette S. Kim, Patrick Y. Wen, Kin-Hoe Chow, Keith L. Ligon, Scott R. Manalis
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-10-01
coleção:Cell Reports
Assuntos:
functional drug susceptibility testing
glioblastoma
cancer
cell mass
cell size
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221112472101247X
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