PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry

Abstract Background Prostate cancer (PrCa) is one of the most genetically driven solid cancers with heritability estimates as high as 57%. Men of African ancestry are at an increased risk of PrCa; however, current polygenic risk score (PRS) models are based on European ancestry groups and may not be...

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Auteurs principaux:	Meghana S. Pagadala, Joshua A. Linscott, James V. Talwar, Tyler M. Seibert, Brent Rose, Julie Lynch, Matthew Panizzon, Richard Hauger, Moritz H. Hansen, Jesse D. Sammon, Matthew H. Hayn, Karim Kader, Hannah Carter, Stephen T. Ryan
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2022-12-01
Collection:	BMC Cancer
Sujets:	Prostate Cancer Prostate Cancer Risk Single nucleotide polymorphism (SNP) Ancestry African Polygenic Risk Score (PRS)
Accès en ligne:	https://doi.org/10.1186/s12885-022-10258-3
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