Label-free affinity screening, design and synthesis of inhibitors targeting the Mycobacterium tuberculosis L-alanine dehydrogenase.

The ability of Mycobacterium tuberculosis (Mtb) to persist in its host may enable an evolutionary advantage for drug resistant variants to emerge. A potential strategy to prevent persistence and gain drug efficacy is to directly target the activity of enzymes that are crucial for persistence. We pre...

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Detalhes bibliográficos

Principais autores:	Heung-Bok Kim, John-Paul Bacik, Ruilian Wu, Ramesh K Jha, Michaeline Hebron, Catherine Triandafillou, Joseph E McCown, Nam-In Baek, Jeong Han Kim, Young Jae Kim, Celia W Goulding, Charlie E M Strauss, Jurgen G Schmidt, Gauri S Shetye, Sungweon Ryoo, Eun-Kyeong Jo, Young Ho Jeon, Li-Wei Hung, Thomas C Terwilliger, Chang-Yub Kim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2022-01-01
Colecção:	PLoS ONE
Acesso em linha:	https://doi.org/10.1371/journal.pone.0277670
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