Suppression of Hsp90 expression in Aspergillus fumigatus enhances sensitivity to oxidative stress and activates host cell NF-κB p65 and ERK signaling pathways

ABSTRACT This study investigates the pivotal role of the molecular chaperone Hsp90 in the growth, development, and immune modulation of the opportunistic pathogen Aspergillus fumigatus. Using a Tet-on system-based conditional expression strain, Tet-hsp90, we demonstrate that Hsp90 is essential for t...

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Үндсэн зохиолчид:	Lingyun Song, Deqi Jiang, Xiaogang Zhou, Xiaokang Yi, Shihan Jia, Yasheng Li, Lei Zhang, Jiabin Li, Jinxing Song
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	American Society for Microbiology 2026-04-01
Цуврал:	mBio
Нөхцлүүд:	Hsp90 Aspergillus fumigatus oxidative stress immune responses fungal pathogens
Онлайн хандалт:	https://journals.asm.org/doi/10.1128/mbio.00094-26
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!