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Ancestry-informative regulatory variants at KCNB1 modulate adipogenesis and body mass index

IntroductionObesity and related metabolic disorders represent a major global health burden, yet their genetic determinants remain incompletely characterized, particularly in non-European populations. We aimed to identify body mass index (BMI)–associated loci in an admixed Brazilian population and to...

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Auteurs principaux: Samantha Kuwada Teixeira, Caroline Pancera Laurindo, Fábio Takeo Sato, Luiz Fernando Goda Zuleta, Nubia E. Duarte, Ana Vitória V. Jensen, Samantha L. G. Paço, Alexandre C. Pereira, Noboru Sakabe, Marcelo Nobrega, Jose Eduardo Krieger
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2026-05-01
Collection:Frontiers in Endocrinology
Sujets:
adipogenesis
admixed population
ancestry-specific variants
BMI
body composition
KCNB1
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fendo.2026.1805824/full
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