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Development of a CRISPR-Cas13-based antiviral strategy against hepatitis E virus

Background & Aims: Effective antiviral drugs remain unavailable for many clinically relevant pathogens, including the hepatitis E virus (HEV). This study aimed to evaluate the CRISPR/Cas13d system as a potential antiviral strategy against HEV. Methods: We developed a reporter assay to screen CRI...

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Principais autores: Emely Richter, Mara Klöhn, Maximilian K. Nocke, Marcel Edgar Friedrich, Daniel Todt, Eike Steinmann, Yannick Brüggemann
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-07-01
Serier:JHEP Reports
Fag:
Hepatitis E virus (HEV)
CRISPR-Cas13
Antivirals
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589555926001564
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