Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer

Abstract Background Alternative splicing complexity plays a vital role in carcinogenesis and cancer progression. Improved understanding of novel splicing events and the underlying regulatory mechanisms may contribute new insights into developing new therapeutic strategies for colorectal cancer (CRC)...

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Principais autores:	Qiang Sun, Ye Han, Jianxing He, Jie Wang, Xuejie Ma, Qianqian Ning, Qing Zhao, Qian Jin, Lili Yang, Shuang Li, Yang Li, Qiaoming Zhi, Junnian Zheng, Dong Dong
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2023-09-01
Series:	Genome Medicine
Assuntos:	Long-read sequencing Alternative splicing TIMP1 Δ4-5 Colorectal cancer
Acceso en liña:	https://doi.org/10.1186/s13073-023-01226-y
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