Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis

Abstract Background Aging is associated with significant structural and functional changes in the spleen, leading to immunosenescence, yet the detailed effects on splenic vascular endothelial cells (ECs) and their immunomodulatory roles are not fully understood. In this study, a single-cell RNA (scR...

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Detalhes bibliográficos

Principais autores:	Yanjing Huang, Zhong Liu, Mengke Li, Dongliang Wang, Jinguo Ye, Qiuling Hu, Qikai Zhang, Yuheng Lin, Rongxin Chen, Xuanwei Liang, Xingyi Li, Xianchai Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-07-01
Colecção:	Immunity & Ageing
Assuntos:	scRNA-seq Spleen Aging Endothelial cell Immunosenescence
Acesso em linha:	https://doi.org/10.1186/s12979-024-00452-1
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