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Reducing the Kidney Uptake of High Contrast CXCR4 PET Imaging Agents via Linker Modifications

Purpose: The C-X-C chemokine receptor 4 (CXCR4) is highly expressed in many subtypes of cancers, notably in several kidney-based malignancies. We synthesized, labeled, and assessed a series of radiotracers based on a previous high contrast PET imaging radiopharmaceutical [<sup>68</sup>Ga]Ga-BL02, wi...

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Principais autores: Daniel Kwon, Zhengxing Zhang, Jutta Zeisler, Hsiou-Ting Kuo, Kuo-Shyan Lin, Francois Benard
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2022-07-01
סדרה:Pharmaceutics
נושאים:
positron emission tomography
oncology
CXCR4
pharmacokinetics
nuclear medicine
גישה מקוונת:https://www.mdpi.com/1999-4923/14/7/1502
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