Structural basis for Polθ-helicase DNA binding and microhomology-mediated end-joining
Abstract DNA double-strand breaks (DSBs) present a critical threat to genomic integrity, often precipitating genomic instability and oncogenesis. Repair of DSBs predominantly occurs through homologous recombination (HR) and non-homologous end joining (NHEJ). In HR-deficient cells, DNA polymerase the...
Сохранить в:
| Главные авторы: | , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Portfolio
2025-04-01
|
| Серии: | Nature Communications |
| Online-ссылка: | https://doi.org/10.1038/s41467-025-58441-x |
| Метки: |
Нет меток, Требуется 1-ая метка записи!
|