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Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.

A common haplotype on 10q26 influences the risk of age-related macular degeneration (AMD) and encompasses two genes, LOC387715 and HTRA1. Recent data have suggested that loss of LOC387715, mediated by an insertion/deletion (in/del) that destabilizes its message, is causally related with the disorder...

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Principais autores: Zhenglin Yang, Zongzhong Tong, Yuhong Chen, Jiexi Zeng, Fang Lu, Xufang Sun, Chao Zhao, Kevin Wang, Lisa Davey, Haoyu Chen, Nyall London, Daisuke Muramatsu, Francesca Salasar, Ruben Carmona, Daniel Kasuga, Xiaolei Wang, Matthew Bedell, Manjuxia Dixie, Peiquan Zhao, Ruifu Yang, Daniel Gibbs, Xiaoqi Liu, Yan Li, Cai Li, Yuanfeng Li, Betsy Campochiaro, Ryan Constantine, Donald J Zack, Peter Campochiaro, Yinbin Fu, Dean Y Li, Nicholas Katsanis, Kang Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2010-02-01
coleção:PLoS Genetics
Acesso em linha:https://doi.org/10.1371/journal.pgen.1000836
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