Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK

Abstract Phospholipase C β (PLCβ) is involved in diverse biological processes, including inflammatory responses and neurogenesis; however, its role in bone cell function is largely unknown. Among the PLCβ isoforms (β1–β4), we found that PLCβ4 was the most highly upregulated during osteoclastogenesis...

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Principais autores:	Dong-Kyo Lee, Xian Jin, Poo-Reum Choi, Ying Cui, Xiangguo Che, Sihoon Lee, Keun Hur, Hyun-Ju Kim, Je-Yong Choi
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group 2025-02-01
Serija:	Experimental and Molecular Medicine
Online dostop:	https://doi.org/10.1038/s12276-025-01390-8
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