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Therapeutic implications of current Janus kinase inhibitors as anti-COVID agents: A review

Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been implicated in immunopathogenesis of COVID-19 infection under different stages such as viral entry, escaping innate immunity, replicatio...

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Principais autores: Nem Kumar Jain, Mukul Tailang, Hemant Kumar Jain, Balakumar Chandrasekaran, Biswa Mohan Sahoo, Anandhalakshmi Subramanian, Neelaveni Thangavel, Afaf Aldahish, Kumarappan Chidambaram, M. Alagusundaram, Santosh Kumar, Palani Selvam
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-03-01
coleção:Frontiers in Pharmacology
Assuntos:
Janus kinase
JAKs
JAK-STAT pathway
JAKi
Jakinibs
kinase inhibitors
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2023.1135145/full
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