Inhibition of macrophage infectivity potentiator in Burkholderia pseudomallei suppresses pro-inflammatory responses in murine macrophages

IntroductionMelioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is a disease endemic in many tropical countries globally. Clinical presentation is highly variable, ranging from asymptomatic to fatal septicemia, and thus the outcome of infection can depend on the host immune...

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Autors principals:	Jua Iwasaki, Nicole M. Bzdyl, Dion J. M. Lin-Sullivan, Nicolas J. Scheuplein, Maria Emilia Dueñas, Emma de Jong, Nicholas J. Harmer, Ulrike Holzgrabe, Mitali Sarkar-Tyson
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2024-03-01
Col·lecció:	Frontiers in Cellular and Infection Microbiology
Matèries:	Burkholderia pseudomallei macrophage infectivity potentiator small-molecule inhibitor immune response RNA sequencing
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcimb.2024.1353682/full
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