Tumour-Associated Hypoxia: Can We Give Chimeric Antigen Receptor T Cells More Breathing Space?

Immunotherapy using chimeric antigen receptor (CAR)-engineered T cells has encountered important limitations in the transition of their use from liquid to solid tumours. Success is dependent upon T-cell trafficking to, and functional persistence within, tumours that often present a metabolically and...

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Bibliografiska uppgifter

Huvudupphov:	Karen I Larios Martinez, Paris Kosti, Anna Schurich, James N Arnold, John Maher
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	European Medical Journal 2020-09-01
Serie:	European Medical Journal
Ämnen:	adoptive cell therapy chimeric antigen receptor (car) car-t cells hypoxiainducible factor-1-α (hif1-α) hypoxia-responsive elements (hre) hypoxia on-target off-tumour immunotherapy oncology oxygen-sensitive car
Länkar:	https://www.emjreviews.com/oncology/article/editors-pick-tumour-associated-hypoxia-can-we-give-chimeric-antigen-receptor-t-cells-more-breathing-space/
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