E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

Class II HLH proteins heterodimerize with class I HLH/E proteins to regulate transcription. Here, we show that E proteins sharpen neurogenesis by adjusting the neurogenic strength of the distinct proneural proteins. We find that inhibiting BMP signaling or its target ID2 in the chick embryo spinal c...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Gwenvael Le Dréau, René Escalona, Raquel Fueyo, Antonio Herrera, Juan D Martínez, Susana Usieto, Anghara Menendez, Sebastian Pons, Marian A Martinez-Balbas, Elisa Marti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2018-08-01
coleção:	eLife
Assuntos:	E proteins proneural proteins neurogenesis neuronal differentiation ID proteins bone morphogenetic proteins
Acesso em linha:	https://elifesciences.org/articles/37267
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!