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PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

ABSTRACT Polybromo 1 (PBRM1) ranks as the second most commonly mutated gene in clear cell renal cell carcinoma (ccRCC), while its role in immune escape remains elusive. We developed a PBRM1‐knockout mice model to perform single‐cell RNA sequencing, which demonstrated a substantial population of immu...

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Kaydedildi:
Asıl Yazarlar: Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2026-03-01
Seri Bilgileri:Advanced Science
Konular:
cancer‐associated fibroblasts
immunotherapy
PBRM1
tumor‐associated macrophages
Online Erişim:https://doi.org/10.1002/advs.202512627
Etiketler: Etiketle
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