Fibroblast-derived matrix human skin equivalents reveal distinct roles for papillary and reticular fibroblasts in human skin barrier integrity and aging

Abstract The lipidic skin barrier can be compromised by skin aging, driven by internal and external factors. With age the reticular dermal layer increases, suggesting that changes in the dermal phenotype influences skin barrier integrity with age. Fibroblast-derived matrix human skin equivalents (FD...

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Ngā kaituhi matua:	Alesha Louis, Catherine Mergen, Marion H. Rietveld, Gaëlle Gendronneau, Nada Andre, Youcef Ben Khalifa, Joke A. Bouwstra, Robert Rissmann, Rym Halkoum, Abdoelwaheb El Ghalbzouri
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2026-04-01
Rangatū:	Scientific Reports
Ngā marau:	Skin aging Human skin equivalents Stratum corneum Lipid packing Ceramides
Urunga tuihono:	https://doi.org/10.1038/s41598-026-48648-3
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!