Innate immune pathway activated mesenchymal stromal cells improve function and histologic outcomes in a rodent osteoarthritis model

IntroductionIntra‐articular administration of mesenchymal stromal cells (MSC) has demonstrated anti‐inflammatory and chondroprotective activity in both preclinical models and in randomized clinical trials in patients with osteoarthritis (OA). Nonetheless, precedent from MSC studies in non‐OA models...

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Autores principales:	Cody Plaisance, Lyndah Chow, Renata Impastato, Zoë J. Williams, Isabella Sabino, Katie J. Sikes, Kelly S. Santangelo, Steven Dow, Lynn M. Pezzanite
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-05-01
Colección:	Frontiers in Bioengineering and Biotechnology
Materias:	osteoarthritis mesenchymal stromal cell regenerative therapies STING interferon
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1525969/full
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