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Patient-Derived Organoids as a Platform to Decipher and Overcome Radioresistance: From the Tumor Microenvironment to Radiosensitizer Discovery

Patient-derived organoids (PDOs) preserve patient genotypes and 3D architecture, offering a useful platform to investigate mechanisms of radioresistance and test radiosensitizers. We outline an end-to-end workflow—model establishment, multi-omics profiling, pharmacologic screening, and in vivo confi...

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Principais autores: Dashan Yin, Xiujuan Hong, Xiaoqi Wang, Wenjia Ding, Chenli Wang, Jin Qian, Yi Zhou, Chuan Sun, Zhibing Wu
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2025-12-01
סדרה:Current Oncology
נושאים:
patient-derived organoids (PDOs)
radioresistance
radiosensitizers
radiotherapy (RT)
tumor microenvironment (TME)
cancer stem cells (CSCs)
גישה מקוונת:https://www.mdpi.com/1718-7729/32/12/680
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