Rus-GXF, a ruscogenin glycoside, binds to the ADP-binding domain of JAK1 to prevent inflammation and barrier damage in acute lung injury

BackgroundRuscogenin-1-O-[β-D-glucopyranosyl (1→2)][β-D-xylopyranosyl (1→3)] -β-D-fucopyranoside (Rus-GXF) is a ruscogenin glycoside of Liriope muscari (Decaisne) L. H. Bailey, yet its protective effects against acute lung injury—a condition characterized by exacerbated inflammation and barrier dama...

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Bibliografische Detailangaben

Hauptverfasser:	Long Liu, Xu Duan, Mei-Qi Li, Yi Gu, Jia-He Zhao, Kai-Shuai Si, Nan-Nan Wang, Xing-Fu Chen, Zhong-Qiong Yin, Li-Xia Li, Xun Zhou, Chun Wu, Meng-Liang Tian, Yuan-Feng Zou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-03-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	acute lung injury inflammation JAK1/STAT3 kinase inhibitor molecule
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1730503/full
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