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Insects evolved a monomeric histone-fold domain in the CENP-T protein family

Abstract The histone-fold domain (HFD) is a conserved protein interaction module that requires stabilization through a handshake interaction with an HFD partner. All HFD proteins known to date form obligate dimers to shield the extensive hydrophobic residues along the HFD. Here, we find that the lep...

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Autori principali: Sundar Ram Sankaranarayanan, Jonathan Ulmer, Anna Mørch, Ahmad Ali-Ahmad, Nikolina Sekulić, Ines Anna Drinnenberg
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Nature 2025-10-01
Serie:EMBO Reports
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Accesso online:https://doi.org/10.1038/s44319-025-00603-5
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