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The tumor mutational landscape of BRCA2-deficient primary and metastatic prostate cancer

Abstract Carriers of germline BRCA2 pathogenic sequence variants have elevated aggressive prostate cancer risk and are candidates for precision oncology treatments. We examined whether BRCA2-deficient (BRCA2 d ) prostate tumors have distinct genomic alterations compared with BRCA2-intact (BRCA2 i )...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kevin H. Kensler, Shakuntala Baichoo, Shailja Pathania, Timothy R. Rebbeck
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Portfolio 2022-06-01
Cyfres:npj Precision Oncology
Mynediad Ar-lein:https://doi.org/10.1038/s41698-022-00284-6
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