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Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).

The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle remain unclear.We examine interactions betwee...

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Principais autores: Naoki Sakane, Hye-Sook Kwon, Sara Pagans, Katrin Kaehlcke, Yasuhiro Mizusawa, Masafumi Kamada, Kara G Lassen, Jonathan Chan, Warner C Greene, Martina Schnoelzer, Melanie Ott
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2011-08-01
Serier:PLoS Pathogens
Online adgang:http://europepmc.org/articles/PMC3158049?pdf=render
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