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Binding Heterogeneity of <named-content content-type="genus-species">Plasmodium falciparum</named-content> to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

ABSTRACT Cerebral malaria is a severe neurological complication associated with sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the brain microvasculature, but the specific binding interactions remain under debate. Here, we have generated an engineered three-dimensional (3D) hum...

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Principais autores: Maria Bernabeu, Celina Gunnarsson, Maria Vishnyakova, Caitlin C. Howard, Ryan J. Nagao, Marion Avril, Terrie E. Taylor, Karl B. Seydel, Ying Zheng, Joseph D. Smith
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019-06-01
Serier:mBio
Fag:
PfEMP1
Plasmodium falciparum
cerebral malaria
microvessels
tissue engineering
Online adgang:https://journals.asm.org/doi/10.1128/mBio.00420-19
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