Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

<h4>Context</h4>Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the Wnt/β-catenin signaling pathw...

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Detalhes bibliográficos

Principais autores:	Sébastien Gaujoux, Constanze Hantel, Pierre Launay, Stéphane Bonnet, Karine Perlemoine, Lucile Lefèvre, Marine Guillaud-Bataille, Felix Beuschlein, Frédérique Tissier, Jérôme Bertherat, Marthe Rizk-Rabin, Bruno Ragazzon
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2013-01-01
coleção:	PLoS ONE
Acesso em linha:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23409032/?tool=EBI
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