Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3

Abstract Dynamic remodelling of the extracellular matrix (ECM) is a key feature of cancer progression. Enzymes that modify the ECM, such as matrix metalloproteinases (MMPs), have long been recognised as important targets of anticancer therapy. Inflammatory cytokines are known to play a key role in r...

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Главные авторы:	Samuel J. Cutler, James D. Doecke, Ibtisam Ghazawi, Jinbo Yang, Lyn R. Griffiths, Kevin J. Spring, Stephen J. Ralph, Albert S. Mellick
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2017-08-01
Серии:	Scientific Reports
Online-ссылка:	https://doi.org/10.1038/s41598-017-08581-y
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