Assembly of the Mycobacterium tuberculosis type VII ESX-1 secretion system in Mycobacterium smegmatis identifies a new transcriptional activator of esx-1 genes and a novel TB vaccine

ABSTRACT Mycobacterium tuberculosis (M. tb) uses its type VII secretion system (T7SS) ESX-1 to export immunogenic, virulence-mediating protein effectors. In this study, the fast-growing, non-pathogenic model mycobacteria Mycobacterium smegmatis mc2-155 was engineered to express the M. tb T7SS ESX-1...

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Hlavní autoři: Slim Zriba, Ze Long Lim, Marlene Snider, Nirajan Niroula, Marie Hardouin, Jeffrey M. Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2025-10-01
Edice:Microbiology Spectrum
Témata:
M. tuberculosis
M. smegmatis
type-7 secretion system
ESX-1
On-line přístup:https://journals.asm.org/doi/10.1128/spectrum.01131-25
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