Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes, mTORC1 and mTORC2, plays a central role in the regulation of cellular growth, metabolism and migration. A dysregulation of the mTOR pathway has in turn been implicated in several pathological conditions includin...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Pei Shi Ong, Louis Z Wang, Xiaoyun Dai, Sheng Hsuan Tseng, Shang Jun Loo, Gautam Sethi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2016-10-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	Insulin Resistance Cancer Cancer stem cell chemoresistance rapamycin Mechanistic target of rapamycin
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00395/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!