Hepatic metastasis of mucinous adenocarcinoma with neuroendocrine differentiation harboring a rare HER2 R678Q mutation: a case report and literature review

BackgroundCancer of unknown primary (CUP) remains a diagnostic and therapeutic challenge, particularly when involving rare histological and molecular subtypes. Mucinous adenocarcinoma (MAC) with neuroendocrine differentiation is exceptionally rare, and its molecular characteristics are poorly unders...

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Auteurs principaux:	Zhitao Chen, Chenchen Ding, Yangjun Gu, Qiyong Li
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2026-06-01
Collection:	Frontiers in Oncology
Sujets:	cancer of unknown primary HER2 mutation mucinous adenocarcinoma neuroendocrine differentiation trastuzumab
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1814733/full
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