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Dynamic regulation of NeuroD1 expression level by a novel viral construct during astrocyte-to-neuron reprogramming

Astrocyte-to-neuron reprogramming presents a viable approach for regenerative medicine. The reprogramming factor NeuroD1 has demonstrated the capability of neuronal reprogramming with high efficiency and yet primarily glutamatergic neuronal subtype. However, diversified neuronal subtypes are needed...

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Principais autores: Natalie Mseis-Jackson, Mei Jiang, Mehek Sharma, Arya Ranchod, Christine Williams, Xuanyu Chen, Hedong Li
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-12-01
coleção:Molecular Therapy: Nucleic Acids
Assuntos:
MT: Oligonucleotides: Therapies and Applications
astrocyte
microRNA
miR-124
NeuroD1
neuronal reprogramming
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2162253125002586
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