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Multiple-Molecule Drug Repositioning for Disrupting Progression of SARS-CoV-2 Infection by Utilizing the Systems Biology Method through Host-Pathogen-Interactive Time Profile Data and DNN-Based DTI Model with Drug Design Specifications

The coronavirus disease 2019 (COVID-19) pandemic has claimed many lives since it was first reported in late December 2019. However, there is still no drug proven to be effective against the virus. In this study, a candidate host–pathogen–interactive (HPI) genome-wide genetic and epigenetic network (...

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Principais autores: Cheng-Gang Wang, Bor-Sen Chen
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-11-01
Serier:Stresses
Fag:
SARS-CoV-2
COVID-19
systems biology
reverse engineering
principal network projection (PNP)
drug–target interaction (DTI) model
Online adgang:https://www.mdpi.com/2673-7140/2/4/29
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