C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

Abstract Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear. Furthermore, its potential as a therapeutic target t...

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Κύριοι συγγραφείς:	Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2022-08-01
Σειρά:	Acta Neuropathologica Communications
Θέματα:	C5aR1 Alzheimer’s disease Microglia Complement Neuroinflammation DAM
Διαθέσιμο Online:	https://doi.org/10.1186/s40478-022-01416-6
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