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CD47 knockout mice exhibit improved recovery from spinal cord injury

Recent data have implicated thrombospondin-1 (TSP-1) signaling in the acute neuropathological events that occur in microvascular endothelial cells (ECs) following spinal cord injury (SCI) (Benton et al., 2008b). We hypothesized that deletion of TSP-1 or its receptor CD47 would reduce these pathologi...

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Autori principali: Scott A. Myers, William H. DeVries, Kariena R. Andres, Mark J. Gruenthal, Richard L. Benton, James B. Hoying, Theo Hagg, Scott R. Whittemore
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2011-04-01
Serie:Neurobiology of Disease
Soggetti:
CD47
Thrombospondin-1
Spinal cord injury
Microvasculature
Angiogenesis
Inflammation
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996110004031
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