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Analysis of retrotransposon subfamily DNA methylation reveals novel early epigenetic changes in chronic lymphocytic leukemia

Retrotransposons such as LINE-1 and Alu comprise >25% of the human genome. While global hypomethylation of these elements has been widely reported in solid tumours, their epigenetic dysregulation is yet to be characterised in chronic lymphocytic leukaemia, and there has been scant consideration of...

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Autori principali: Timothy M. Barrow, Nicole Wong Doo, Roger L. Milne, Graham G. Giles, Elaine Willmore, Gordon Strathdee, Hyang-Min Byun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2020-01-01
Serie:Haematologica
Accesso online:https://haematologica.org/article/view/9594
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