Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection

Abstract Background Natural killer (NK) cells play an important first-line role against tumour and viral infections and are regulated by inhibitory receptor expression. Among these inhibitory receptors, the expression, function, and mechanism of cluster of differentiation 47 (CD47) on NK cells durin...

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Principais autores:	Bin Lang, Meiting Wang, Zining Zhang, Yajing Fu, Xiaoxu Han, Qinghai Hu, Haibo Ding, Hong Shang, Yongjun Jiang
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2023-11-01
Serija:	Journal of Translational Medicine
Teme:	CD47 TSP1 IFN-γ NK cells JAK–STAT3 HIV infection
Online dostop:	https://doi.org/10.1186/s12967-023-04667-6
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