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Comparative immunological landscape between pre- and early-stage LUAD manifested as ground-glass nodules revealed by scRNA and scTCR integrated analysis

Abstract Background Mechanism underlying the malignant progression of precancer to early-stage lung adenocarcinoma (LUAD) as well as their indolence nature remains elusive. Methods Single-cell RNA sequencing (scRNA) with simultaneous T cell receptor (TCR) sequencing on 5 normal lung tissues, 3 preca...

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Principais autores: Ziqi Wang, Li Yang, Wenqiang Wang, Huanhuan Zhou, Juan Chen, Zeheng Ma, Xiaoyan Wang, Quncheng Zhang, Haiyang Liu, Chao Zhou, Zhiping Guo, Xiaoju Zhang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-11-01
Serier:Cell Communication and Signaling
Fag:
Ground glass nodule
Lung adenocarcinoma
scRNA-seq
ScTCR-seq
Tumor microenvironment
Online adgang:https://doi.org/10.1186/s12964-023-01322-x
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